PLYMOUTH – Some might argue that everyone in the Plymouth-Barnstable Senate district loses in this fall’s election.

With incumbent Senate President Therese Murray not seeking re-election next week, the people of Bourne, Falmouth, Kingston, Pembroke, Plymouth and Sandwich are bound to see a drop in their Beacon Hill clout.

But both of the men running to succeed Murray as the district’s senator have many years of legislative experience and are anxious to give the job a try.

Plymouth resident Vinny deMacedo, the Republican candidate, has represented the 1st Plymouth District in the House of Representatives for 16 years. DeMacedo has owned and operated the RWA Mobil station in Cedarville during his eight terms in public office. A former Plymouth town meeting member, he is the longtime ranking minority member of the House Ways and Means Committee.

The Democratic candidate, Falmouth resident Matt Patrick, represented the 3rd Barnstable District in the House for 10 years. Patrick went to work as the executive director of the Westport River Watershed Alliance after losing his bid for a sixth term in 2010.

Both candidates concede that no one will be able to fully replace Murray, but they also point to their many years of experience as the next-best thing.

DeMacedo, who has had a close working relationship with Murray during his years in the House, says he learned a great deal about building relationships with legislators of both parties. He also says he has been guided by an independent perspective and a dedication to bringing all sides together to build consensus.

While Murray carried funding measures for the district through the Senate, deMacedo says he led adoption of many of those same initiatives, such as funding for Plymouth 400, in the House.

Patrick says it would be foolish to think that he or anyone else could fully replace Murray, but he thinks his experience as a businessman, legislator and civic activist would enable him to get things done in the Senate.

Patrick points to his work in closing corporate tax loopholes, writing environmental legislation, securing approval of the Sagamore flyover and getting Entergy to provide all Cape Cod residents with potassium iodide.

More importantly, Patrick says, as a Democrat he would chair a committee and have more access to the Senate president.

Neither of the candidates was born in the district, but both have deep roots in it.

Patrick, 62, is a New Jersey native who went to Upsala College on a football scholarship. He met Louise, his wife of 37 years, in the Peace Corps. They moved to Cape Cod to raise their two children in 1980, and Patrick worked in the building trades before starting his own solar installation business.

He became politically active after joining the fight to save a river in Mashpee from developers, and he became a selectman and town meeting representative before winning his legislative seat in 2001.

In Boston, he built a reputation as an independent thinker, opposing former U.S. Sen. Ted Kennedy and other Cape officials by advocating for Cape Wind’s offshore wind turbines.

He sees the green industry as a key to the region’s future and wants to position the district’s towns to cash in on the coming renewable-energy boom.

DeMacedo, 49, was only 6 months old when his family moved to the United States from Cape Verde. He grew up in Kingston and graduated from Silver Lake Regional High School before getting a business degree from The King’s College in New York in 1987.

DeMacedo opened his business on State Road in Cedarville four years later. He and his wife, Jennifer, have been married for 23 years and have three children.

A fiscal conservative, deMacedo traces his interest in government to his early days in business, when he started to realize the role government played in the success and failure of all businesses.

He says tourism, economic development and the region’s heroin epidemic are the biggest issues facing the district, and he is looking to hold down the high cost of doing business in the state.

Read more campaign coverage at Mass. Political News.